But not all of them score match winning goals to take their teams to the semi-finals of the Champions League.
As touched upon, it's not easy being a top club from outside Europe's "big five" leagues, historically and contemporarily.
Wojciech Szczęsny - making his 50th UEFA club competition appearance - made crucial saves from Ziyech and Van de Beek early in the second half but his resistance was finally broken by Matthijs de Ligt's towering header from Lasse Schöne's corner.
The player's sister, Katia Aveiro also spoke about the brother and Juve's elimination from the Champions League.
If the Italians did secretly underestimate Erik ten Hag's team then the loss is completely deserved. AEK were brushed aside in Athens, Real met the same fate in Madrid and now Juventus.
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Although Juventus are on course to seal an eighth consecutive Serie A title next weekend, they are out of the Coppa Italia, which they had won the four previous seasons.
They also survived a scare when a penalty awarded to Barca for an apparent foul by Fred on Ivan Rakitic was overturned after a VAR review.
Ajax had chances for further goals and Ronaldo's frustration boiled over in stoppage time when he was booked for a lunging tackle from behind near the centre circle. The 19-year-old is wanted by Barcelona with reports from Spain suggesting that a deal is close.
Speaking to brila.net, Kanu who won the Champions League with the club during his playing days said it is a great achievement for the Dutch club to get to this stage in the competition.
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In the history of the Champions League, no players have been better than Lionel Messi and Cristiano Ronaldo. That streak, which has seen Los Blancos collect four European Cups, has come to an end courtesy of little old Ajax. "Well, we are in the semi-finals now", De Light said after Ajax's win in Turin on Tuesday.
"Juve are a really strong team", he added.
Juventus were rocking but, ironically, Ajax's victor came from an old-fashioned header as De Ligt outjumped two defenders to score. But no one could have foreseen the evening in Madrid on March 5, 2019.
Having already eliminated three-time reigning champions Real Madrid in the last 16, Ajax backed up that awesome display thanks to goals from Donny van de Beek and captain Matthijs de Ligt after Cristiano Ronaldo had opened the scoring.
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