The goal left Real stunned and heading out of the competition they have won for the past three seasons.
Ramos was suspended after picking up a booking in the first leg against Ajax which sent him over the disciplinary threshold, and he will be banned for one more European game after he suggested he received the caution on goal.
Ajax passed up further chances before a awful half for the hosts was compounded by injuries to Lucas Vazquez and Vinicius Junior in quick succession. It lasted two minutes, as Lasse Schone sent a bending free-kick into the top corner before Nacho was sent off late on.
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In Tuesday's other game, Tottenham won 1-0 at Borussia Dortmund to go through 4-0 on aggregate, reaching the quarterfinals for the first time since 2011.
"There has not been one single discussion about Gareth leaving Madrid". Ajax lead 2-0 on the night and 3-2 on aggregate! A defeat such as the 4-1 thrashing handed out by Ajax, as well as the "shi**y season" as Dani Carvajal labelled it, should serve as a turning point.
Los Blancos are in the building!
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We don't expect any changes at the back as the duo of Virgil van Dijk and Joel Matip are starting to perform well together. It's football - we don't play Playstation", he said. "Now City can say we win every match, we are going to be champions".
TNT will broadcast Real Madrid versus Ajax in English, and UniMas will broadcast it in Spanish in the United States. There are some brilliant players in that team - David Neres, Matthijs De Ligt, Nicolas Tagfliafico, Hakim Ziyech and Frenkie De Jong will all feature heavily in Champions League highlights over the rest of their fledgling careers.
In Real's previous league game against Levante six days earlier, Bale snubbed his team-mates when they tried to celebrate with him after he scored the winning penalty.
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