They have a tough job to get out of the group now with both Barca and Inter having six points on the board.
Messi almost put the game away twice at the start of the second half, but both times his low curling shots clattered off the left post to keep Spurs trailing by just two goals.
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"This guy, what he does on the football pitch, is just ridiculous".
Coutinho performed a minor miracle to keep the ball in play on the byline with Rakitic launching himself into a sensational 20-yard volley that clipped the post on its way into Lloris' net.
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The France and Spurs captain rushed off his line in the second minute but misjudged the weight of Lionel Messi's pass, with Jordi Alba setting up Philippe Coutinho to score in an unguarded goal.
"He's the best player in history, I'm very happy to play alongside him and learn". Marc-Andre ter Stegen came up with a big save in the first half and, generally speaking, you can assume they'd still win plenty of games even if they conceded an average of one per game due to the prowess of their attack.
Provided with the grandest of stages and 82,000 fans, the Argentine maestro responded by scoring two goals to take his Champions League haul to 105, instigating two others and twice being denied by the same upright.
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Greater Accra Regional Hospital was the first stop of the day, where the two first ladies joined ten mothers and their babies. Melania Trump has made advocating for children her signature issue since becoming first lady.
However, Messi would get his second of the game, slotting home following an initial poor pass from Kieran Trippier.
"He's a fantastic player", Pochettino said after the game.
His performance was reminiscent of the Champions League final at this same venue in 2011 when Messi, then at the peak of his powers, destroyed Manchester United with a spellbinding performance against Sir Alex Ferguson's team.
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You could be somebody that was ideal your entire life, and somebody could accuse you of something. What's happening here has much more to do than even the appointment of a Supreme Court justice".
Spellbound by Messi's magic, Tottenham backed off again moments later as the striker hit the woodwork for a second time. We were handicapped against Barcelona after conceding after one minute.