And Belgium defender Kompany believed it was no more than City deserved - and served as the flawless response to last month's opening group loss at home to Lyon.
Leroy Sane could make his fourth start of the season in attack.
The second half started in the same fashion as the first, and United had to wait until the 60th minute for a sight at goal when Paul Pogba forced Neto into save with a free-kick from distance.
Ernesto Valverde's men have gone an unthinkable three LaLiga games without a win but will bring back Lionel Messi, who was rested for the weekend draw at Athletic Bilbao.
Paul Scholes on ’embarrassing’ Jose Mourinho: Manchester United legend’s tirade in full
Jose Mourinho has recalled Alexis Sanchez to the starting eleven after the Chilean global was axed for the defeat at West Ham on Saturday.
The kick-off time for Manchester United vs Valencia is 8pm, while that of Hoffenheim vs Man City is 5:55pm.
The most shocking result from the first Champions League games was Manchester City losing to Lyon.
They have also failed to score in seven of these games, but perhaps, more worryingly for City fans, they have never kept a clean sheet in any of their 21 Premier League visits to Liverpool.
"We are the leaders again now since the last fixtures and after that game we still want to be number one".
Google's game streaming beta lets you play Assassin's Creed Odyssey for free
You'll need to be 17 or over, in the USA , and have an internet connection capable of at least 25 megabits per second. It has partnered with Ubisoft to build a demo of Project Stream around the upcoming Assassin's Creed Odyssey .
The first goal was the nicest, with Dybala taking a long ball from Leonardo Bonucci first time to give Juve the lead inside five minutes.
Wednesday's session took place in Bad Schonborn, just 10 miles outside Hoffenheim before they flew back from Frankfurt.
"He is one of the best managers in the world", Zabaleta told BT Sport during their coverage of City's Champions League game against Hoffenheim.
City underwent a light session which included fitness drills and a small training match as they recovered from Tuesday night's exertions.
Melania Trump visits ex-slave holding facility in Ghana
Greater Accra Regional Hospital was the first stop of the day, where the two first ladies joined ten mothers and their babies. Melania Trump has made advocating for children her signature issue since becoming first lady.