The plane crash was reported near Clarendon Road and Joe Allen Drive in the Grays Hill area, the sheriff's office said in a news release.
Authorities say a military plane has crashed but the pilot was able to eject from the aircraft in coastal SC.
The statement said that the jet belonged to Marine Fighter Attack Training Squadron 501 stationed at Marine Corps Air Station Beaufort. An F-35B crashed in SC, but there was no casualty.
"The U.S. Marine pilot safely ejected from the single-seat aircraft and is now being evaluated by medical personnel", the Marines said in a statement.
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The Marines said in a statement that an investigation into the cause of the crash is underway.
The Marine F-35B fighter jet was on a routine training mission. It can also take off in a much shorter space than other fighter jets.
On Thursday, the USA carried out its first operation using the F-35B against Taliban targets in Afghanistan, four months after the Israeli military announced it had used the F-35A to carry out two separate strikes.
Global sales are projected at more that 3,000 aircraft, and the programme was likely to last for some 30 to 40 years. Problems include a broken bracket that was blamed for an in-flight fire on a Marine F-35B in October 2016 at MCAS Beaufort, according to a Marine Corps investigation into the incident.
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The F-35 program is expected to cost the Pentagon about $406 billion for 2,456 fighter jets that the services intend to buy, according to the F-35 Joint Program Office.
The crash comes one day after another F-35B conducted the first airstrike for the USA aircraft over Afghanistan.
On Thursday, a Marine F-35B fighter carried out the first combat airstrike by the American version of the costly fighter.
So far, the US military has taken delivery of 245 F-35s, majority to the US Air Force.
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