With the win on Sunday, Djokovic has extended his head-to-head record against Del Potro to 15-4 as the Argentine was unable to upstage the Serb.
The powerful player couldn't hit the ball hard enough with his backhand to threaten top players, let alone the rulers of the sport like Federer, Djokovic and Rafael Nadal.
In the years between toppling Roger Federer in the 2009 final and Sunday's match, del Potro almost quit tennis after undergoing four wrist surgeries, three of them on his left wrist, that left him in a deep depression and had him seriously weighing retirement. When they shout "Ole, ole, ole, ole", that's what I hear.
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Things looked ominous for Del Potro as Djokovic seized control early on, moving magnificently and constructing a number of superb points with precision striking.
Djokovic's victory, coupled with his July triumph at Wimbledon, ties him with Pete Sampras for the most men's Grand Slam singles titles. And it all started with Djokovic getting erked by crowd reaction and constant singing for Del Potro.
Despite not being ranked as high as his contemporaries - Nadal and Federer in the lead up to the US Open, Djokovic was considered as the favourite, and boy, did he live up to the billing!
But instead of that victory proving a launchpad for a sustained challenge at the Grand Slams, Del Potro battled wrist injuries which required four surgeries.
After taking just two points off Del Potro's first three service games, Djokovic, in his 23rd final at the majors, pounced to break for 5-3. "I'm glad that Novak is the champion".
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But with consecutive major trophies at Wimbledon and Flushing Meadows, where he beat Juan Martin del Potro in straight sets in Sunday's final, Djokovic returns to the top three after being out of that range since June 2017.
"There is a lot of significance of me being now shoulder to shoulder in terms of Grand Slam wins with him".
"I don't think it's (the right) time and place to get into other subjects", he said.
"When I had the surgery of my elbow earlier this year, I could truly understand what Juan Martin was going through with his surgeries for 2-3 years that kept him away from tour".
Yet the atmosphere was more positive on Sunday as spectators enjoyed an absorbing contest - again played under the roof of Arthur Ashe Stadium due to rain - between two great friends. A series of missed forehands by del Potro in the tiebreaker put Djokovic back on course.
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