England's time in Russian Federation has largely gone smoothly but one or two concerns have seeped into Southgate's plans over recent days.
Alli is likely to be replaced in the starting line-up by Ruben Loftus-Cheek, with Marcus Rashford or Raheem Sterling also expected to battle it out for a place in the starting line-up.
But despite England's narrow margin of victory over Tunisia, the manager was delighted with what he saw from his side.
"But I've got to say we've got some brilliant, top professionals who are coping really well with that, both in their approach to training and in the conversations they have around the team". Tunisia like to play the ball out from the back and were very patient but Panama are probably more direct.
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"But there's no doubt the further we go in the tournament the more carefully that dynamic needs to be handled by myself and the staff".
Belgium found it tough indeed to break through Panama until Dries Mertens produced a bit of magic, so including Rashford from the start makes flawless sense for England.
Manchester United striker Lukaku took his goals tally to the tournament to four as the Red Devils carved open Tunisia's defence with an impressive attacking display.
Gomez screened the back four well against Belgium, which would be no easy task for any player, let alone a 34-year-old.
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President Trump is condemning the mainstream media for the negative coverage of the joint summit with North Korea . That's OK". "We'll be saving a tremendous amount of money", Trump said in a press conference .
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Kyle Walker expects Panama to give England a tough test on Sunday, insisting the World Cup clash will be no "walkover".
The result in Sochi means Germany join Sweden on three points in Group F, with Mexico in the lead on six points after their earlier victory against South Korea, who have no points after two games.
All told, CONCACAF teams are 1W-2D-2L against England at the World Cup.
'Game of Thrones' stars Kit Harington, Rose Leslie Wednesday
After the wedding at Rayne Church, the newlyweds were showered with rose-petal confetti outside, then hopped into a Land Rover. But this weekend's United Kingdom wedding of the two former " Game of Thrones " co-stars was a much-anticipated event.