The Gaza Strip is but one of the focal points in the Israeli-Palestinian conflict.
The Israeli military has said it fired only at "instigators" involved in attacks on soldiers.
Israel says most of those killed were militants.
The numbers were down from the previous Friday, when tens of thousands approached the border in demonstrations that saw Israeli forces kill 19 Palestinians, making it the bloodiest day in Gaza since a 2014 war.
Hamas has refused to give up its weapons - even at the cost of derailing talks on getting Abbas to assume the burden of governing Gaza, seen by Israel and Egypt as a prerequisite for opening Gaza's borders.
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"They said Gaza would give up its principles, its project of liberation and (dream) of return if they starve it, but Gaza is coming out today", he said to protesters east of Khan Yunis. He said the demonstrations would continue, telling the crowds: "We will uproot the borders, we will pluck out their hearts, and we will pray in Jerusalem".
The Israeli government rejects such claims and says terrorists are using the cover of the protests to try to cross illegally into its territory. Gen. Ronen Manelis, an Israeli army spokesman.
As such, the IDF has said that it has thwarted the infiltration attempts and are responding with riot dispersal means, including water cannons to put out the fires, a huge fan to disperse the smoke and live fire in accordance with rules of engagement.
The hundreds of injuries over the past two Fridays of protest have further strained Gaza's already embattled health system.
A United Nations human rights spokeswoman urged Israel to exercise restraint against the Palestinian protesters. I particularly urge Israel to exercise extreme caution with the use of force in order to avoid casualties.
The Palestinian Foreign Ministry has called on the global community to find a new formula that would deny the US the right to veto Security Council resolutions demanding the establishment of an independent inquiry commission on events in Gaza.
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Palestinian UN Ambassador Riyad Mansour told reporters at UN headquarters in NY that the USA rejection is very irresponsible. If the Security Council fails to act then the Palestinian side could take the issue to the wider UN General Assembly, he added.
The Palestine Red Crescent Society has "also warned of a shortage of medical supplies and of personal protective equipment for their 400-person team deployed across Gaza".
Gaza: Israel has made a decision to ban the entry of auto tires into the Gaza Strip through the Kerem Shalom commercial crossing, a Palestinian official said on Saturday.
Israel has pointed to violent incidents along the border as evidence of Hamas's true aims.
Hamas has acknowledged some belonged to its military wing, taking part in "popular events".
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