The gunman was identified as the 17-year-old Austin Wyatt Rollins.
Two students - the girl, who is 16, and a 14-year-old boy - were taken to hospitals, where the girl was listed in stable condition and the boy in good condition, according to hospital statements.
"There is an indication that a prior relationship existed between the shooter and the female victim", said St. Mary's County Sheriff Tim Cameron.
Last month in Vermont, a school resource officer responded to a student's report that a fellow student had left a voicemail outlining a mass shooting plot. It is also unclear if the simultaneous shot from the gunman was being aimed at the officer or not.
The attack, which lasted less than a minute, ended after the school resource officer, Deputy 1st Class Sheriff Blaine Gaskill, ran inside the building and engaged with Rollins, with both firing a single round nearly simultaneously. "This is something we train, practice and in reality, hope would never come to fruition. Kids go to school every day (expecting) to be safe, and they're not". The shooting on Tuesday ironically took place 6 days after the student body's own gun control walkout and 4 days before the nationwide March For Our Lives, a protest organized by the Parkland survivors and advocated for by dozens of celebrities.
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"I can tell you that Americans are listening to our students", he said.
"All my daughter said is she was hiding", a father said as law officers and rescue crews continued their response.
A school shooter injured 2 people before being intercepted by the school resource officer.
Great Mills High School is in Great Mills, Maryland, about 70 miles southeast of Washington, D.C. It has more than 1,500 students, about 56% of them minority students, and its four-year graduation rate is 91%, according to the school's 2015-16 improvement plan.
In one example, in Arapahoe County, Colorado, a school resource officer was credited with helping to end a 2013 fatal high school shooting after he approached the gunman's position in the library.
Maryland Gov. Larry Hogan and Rep. Steny Hoyer tweeted that they're monitoring reports and urged people to follow the instructions of local law enforcement at the scene.
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A school shooting has wounded two teenagers at a high school in the U.S. state of Maryland, local authorities say. He said it's now for Congress to take action.
Neighbors in a nearby community prayed for their friends and colleagues during a small vigil following a shooting at southern Maryland school.
The school is attended by almost 1,600 students, news media reports say.
LISTEN: Sheriff Cameron news conference at 11:30 a.m. Tuesday.
Great Mills High School will be closed tomorrow.
"We are Here for you, students of Great Mills", student activist Emma Gonzalez tweeted.
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