Ibuprofen Use Linked to Compensated Hypogonadism in Males

Ibuprofen Use Linked to Compensated Hypogonadism in Males

Ibuprofen Use Linked to Compensated Hypogonadism in Males

"Our immediate concern is for the fertility of men who use these drugs for a long time", said David Møbjerg Kristensen at the University of Copenhagen. Fourteen of them took a daily dosage of ibuprofen that many professional and amateur athletes take: 600 milligrams twice a day. "Taken together, these in vivo data suggest that ibuprofen induced a state of compensated hypogonadism during the trial..." the study states.

A new study suggests that some men who regularly take the anti-inflammatory drug ibuprofen could be doing serious damage to their testicles, or at least the stuff stored inside them, CNN reported Tuesday. It's also not clear whether the same hormonal effects would be seen in men taking lower doses of ibuprofen, or whether the effects are reversible, particularly in men who take ibuprofen for long periods, study co-author Bernard Jégou, director of the National Institute for Research on Environmental and Occupational Health in France, told CNN. "These compounds are good painkillers, but a certain amount of people in society use them without thinking of them as proper medicines".

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The Consumer Healthcare Products Association is a trade group that represents manufacturers of over-the-counter medications and supplements. Jegou, however, warned against taking the drug for months beyond what it necessary.

Scientists analyzed the hormones and blood of a group of 31 healthy white men between 18 and 35 years old over the course of six weeks.

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The researchers found that prolonged ibuprofen use suppressed "important aspects of testicular function, including testosterone production". "The risk is greater than the benefit". This is because the pituitary gland at the base of the brain had ramped up levels of another hormone that drives the production of extra testosterone.

The new study is a continuation of research that first began with pregnant women, Jégou told CNN, in which the researchers examined the health effects when a mother-to-be took one of three mild pain relievers found in medicine chests around the globe: aspirin, acetaminophen (also known as paracetamol and sold under the brand name Tylenol) and ibuprofen.

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