The first half ended goalless, as the visitors held their own at Old Trafford.
Manchester United reached the fourth round of the 2018 FA Cup after beating Championship side Derby County 2-0 at Old Trafford on Friday, thanks to goals from Jesse Lingard and substitute Romelu Lukaku.
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More crosses were massively evading their targets, and he sent the opposition on a counter-attack with a disastrous pass backwards eventually finding it's way to Sam Winnall on the edge of the area - luckily for Mkhitaryan, his shot was skewed well wide.
Rashford's finishing let the hosts' approach play down, though, when the striker skied over the bar after being played through. Passage to the next round keeps the 2016 winners involved, but Mourinho will know his side need to play a lot better to go on and lift the cup come May.
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Tom Huddlestone had a 50th minute shot deflect wide for a corner, before Carson was forced to save from Mata at the other end.
Pogba then curled one wide of Carson's post moments later as both teams had opportunities after the restart.
Tom Lawrence almost sent Derby ahead two minutes before the hour with a thumping shot from just outside the box but Sergio Romero made a brilliant save at the bottom corner.
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Lingard and Lukaku spared the home side's blushes, but questions will remain over United's ability to get over the line in games, with the 2-0 win over Everton last time out ending a run of four matches without a victory - including a shock 2-1 defeat to Bristol City in the EFL Cup quarter-finals.