Arsenal's silky German Maestro frequently pops up in the number 10 role, drifting behind the striker and pulling strings in between the lines of midfield and attack, meaning that Palace's Serbian stalwart Luka Milivojevic will be the unlucky man facing Ozil come Thursday night.
Wenger's side gradually took charge and they forced the breakthrough in the 24th minute when Palace's failure to clear Mesut Ozil's free-kick eventually led to Mustafi's opening goal.
Andros Townsend, a former Tottenham Hotspur player, levelled the match five minutes after the restart, however, a quick-fire brace from Alexis Sanchez ensured Arsenal would head back to North London with the three points.
The hosts had been the first to threaten when Yohan Cabaye struck just wide of the left post from 25 yards, but it was then that Arsenal's first period of dominance began.
Chilly weather could be contributing to the state's 'widespread' flu epidemic
This year it is speculated that the vaccine may only be about 10% effective. "That generally differentiates from a flu to a cold". These usually dissipate within two days and are considered a normal reaction to being injected with latent strains of the virus.
At that point Palace were in the ascendancy but Sanchez's quick double soon killed off the home side's hopes.
Arsenal required time to recover from the setback, and it was only after a lethargic clearance from Christian Benteke after the hour mark that the Gunners were gifted the chance they needed.
Despite leading, Arsenal's form this season meant only another goal would make victory look likely, and its fans had to wait only four more minutes.
Putin says St Petersburg blast was terrorist act
Petersburg subway after a suicide bombing by a radical Islamist who was born in the central Asian republic of Kyrgyzstan. The Investigative Committee has launched a criminal case on the grounds of attempted mass murder after the blast.
With a brilliant chipped-pass from inside his own half, Jack Wilshere - often peripheral this season - sent Sanchez into space in the Palace area and, after he impressively controlled, the Chilean routinely poked beyond Speroni.
Discouragingly for Wenger, amid Palace's pressure and obvious ambitions, they scored another late goal his team did little to resist.
James Tomkins gave Palace a lifeline on 89 minutes with a headed consolation from Townsend's corner but the Eagles ran out of time.
Home and Away actress in critical condition after two-car collision
The actress is now in St George Hospital and her sister is in Liverpool Hospital. The driver of the other auto also died.