Nadal broke Isner's serve at 5-4 in the first set and then recovered from 15/40 in the second game of the second set before sweeping through the tie-break.
The top-seeded Spaniard eased to his 59th victory of the year, breaking sixth seed Isner at 5-4 and holding his nerve to sweep a second-set tiebreak. The big-serving American defeated Leonardo Mayer, 6-0, 6-3.
They even went fishing together, but Nadal said they will have their game faces on for today: "At the end of the day we are competitors".
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Lombardo said Paddock shot from the hotel window down at the crowd of about 22,000 at a country music concert late Sunday for about nine minutes in total.
"Everybody knows that he serves huge and it is so hard to break him". However, Isner is in for a tough match as he has yet to beat Nadal in their seven clashes.
Andrey Rublev ensured a continued Russian presence in the men's draw as he sprang a surprise in fighting back to oust seventh seed Tomas Berdych 1-6, 6-4, 6-1.
Nick Kyrgios also advanced.
"I think it was just a hair or something, a hair from the tennis ball".
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The study also found that using voice commands is more demanding than using the touch screen and buttons on a dashboard. Removing eyes from the road for just two seconds doubles the risk for a crash, according to previous research.
Petra Kvitova, the two-time Wimbledon champion from the Czech Republic, faces Caroline Garcia of France in the other semi-final.
It's been a rocky road for the Bulgarian as well, needing three sets to quell the challenge of Damir Dzumhur 6-1, 3-6, 6-3 in the first round.
Cirstea follows fellow Romanian Simona Halep into the quarterfinals after the second seed sent Maria Sharapova packing on Wednesday.
Cirstea, ranked 44th in the world, stunned Czech Pliskova 6-1, 7-5 to reach the last eight. I'm happy for him that he's having a good year.
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On the women's side, unseeded Carolina Garcia of France upset third-seeded Elina Svitolina of Ukraine 6-7 (5), 7-5, 7-6 (6) in nearly 3 1/2 hours to line up Petra Kvitova in the semifinals.