"It will be a demanding game, especially after just three days and the travelling but we have to handle the situation", the Spaniard said.
That was so rarely the case last season but City, right now, are on a roll.
Aguero made it nine goals in five games against Watford and with two simple first-half strikes from close range and a brilliant second-half solo goal, while Jesus scored his 11th goal in 13 Premier League starts since joining the club in January.
Steven Davis scored the only goal of the game after just six minutes when he tucked the ball home after Palace keeper Wayne Hennessey palmed a Dusan Tadic cross into his path.
World T20 Champions all set for Pakistan tour
The PCB has had to rely on heavy financial incentives for the visiting players to draw them to the country so far. Former Pakistan skipper Misbah Ul- Haq and Shahid Afridi made their presence felt on the ground.
Raheem Sterling scored late penalty after coming on as City secured a 6 - 0 win in the league.
Emboldened by a fresh set of full-backs, Guardiola plumped for the 3-5-2 system to kick off the campaign but with the two main men together neither performances nor results were sparkling.
Cramming them both into the team at Boro required a return to the much-maligned 3-5-2 shape, and a 2-2 draw with the eventually relegated side was perhaps more than City deserved.
The victory took City to the top of the table, but Manchester United can join it on Sunday with a win over Everton.
Sergio Aguero has three goals in his last three league appearances against the London side.
Pentagon confirms American ISIS fighter captured in Syria
The US military confirmed on Thursday that an American fighting in Syria for the Islamic State has been taken into custody. The American fighter, whose identity was not released, is not the first American ISIS fighter captured on the battlefield.
Craig Cathcart (knee injury) and Miguel Britos (suspended) are also out but the manager singled out Kaboul as the player Watford could miss the most on the weekend. Miguel Britos serves the second of his three-match ban after being sent off against Brighton. They shouldn't be slept on in the Premier League and they'll cause problems for this Manchester City squad.
The visitors are huge favourites to claim a win at 4/11 odds. We can win at home, away - it doesn't matter where.
"I think we can threaten a lot of teams with the way we are playing and we can have a great season", Watford defender Daryl Janmaat told the Watford Observer newspaper. You can get the best odds of 10/1 for our betting tip at Bet365.
Aguero now has six Premier League hat-tricks.
Pak rangers violate ceasefire on J&K Intn'l Border; 1 BSF jawan killed
India's Border Security Force (BSF) said that Pakistani soldiers fired at several positions along the volatile global border. Pakistani troops have been continuously violating the ceasefire along the IB for the past four months.