Spieth played in a threesome alongside Masters victor Sergio Garcia and Koepka, the U.S. Open champion.
The group's tee time was delayed two minutes because the preceding threesome had not played their second shots at the hole, which is reachable in two shots for most players.
But the world number two, who is chasing the career Grand Slam this week at Quail Hollow, is five shots off the early pace set by Denmark's Thorbjorn Olesen (-4).
Rory McIlroy, a two-time victor at Quail Hollow, and defending champion Jimmy Walker are among those who start in the afternoon half of the draw.
MLB, MLBPA announces creation of Players Weekend
Both MLB and the MLB Players Association collaborated on Players Weekend, billing it as a player-focused field festival. But Players Weekend appears to be the first time that nicknames will be used by a major sport on a league-wide basis.
Spieth also bogeyed the first, one of the new holes constructed at Quail Hollow immediately after it hosted last year's Wells Fargo Championship, after failing to get up and down from a greenside bunker.
"It was a day that should have been a couple under par and ended one-over", Spieth said. "The first hole, got off to a bad [start], I missed a four-footer, and that was kind of my day, it kind of felt like". "It's much easier when you are on the front page of the leaderboard than it is coming from behind".
"This week, I worked hard on it and I got a lot of confidence in the driver". Truth has been working on his "I Got It" single with Charlotte rapper LeeLee and producer Manny Mac, which will be featured on an upcoming EP.
"I'm not trying to sound like a smart aleck (but) surely they didn't move the PGA here on the basis they'd only change three holes".
Jay Cutler Makes Debut at Dolphins Practice
"I don't have to make that announcement right now but (Cutler) didn't come out of retirement to stand on the sidelines". But without a quarterback, or at least a true starting quarterback, they're looking at a wildcard berth at best.
"I did a great job and holed some great putts for pars".
Olesen had only played 13 majors before this week, but was ninth in the Open in 2012 and finished sixth on his Masters debut the following year.
The 28-year-old Englishman, whose bushy beard and jovial personality have made him a fan favorite, had five bogeys and two double bogeys against two birdies before pulling out of the year's final major championship.
"I felt awful about it", Koepka said, although he had not shouted the traditional warning of "fore" following his drive.
South African opposition calls for new election, accused of hallucinating
After nearly two hours of speeches, members of parliament voted in the secret ballot on the floor of the South African Parliament. Zuma's political controversies have drawn attention away from South Africa's pressing long-term economic challenges.